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ACE inhibitors including Lisinopril lower blood pressure level by reducing the creation of angiotensin II, thereby relaxing arterial muscle and enlarging arteries. Older patients, an average of, have (approximately doubled) higher blood levels and area within the plasma concentration time curve (AUC) than younger patients. ACE is essential because it is an enzyme to blame for producing the chemical, angiotensin II. Patients with kidney disease may progress to kidney failure when taking Lisinopril or other ACE inhibitors.
Your pharmacist provides more information regarding Lisinopril. Prinivil had similar effectiveness and negative effects in younger and older ( > 65 years) patients. In addition, it should be noted that Black patients receiving ACE inhibitors have been reported to get a higher incidence of angioedema compared to non-Blacks (see WARNINGS, Anaphylactoid and Possibly Related Reactions, Head and Neck Angioedema). Lisinopril did not produce single strand DNA breaks in an in vitro alkaline elution rat hepatocyte assay.